Biology

Bacteria in heavy water

Experiment developed by scientists from the Centro de Biología Molecular Severo Ochoa and the Universidad Autónoma de Madrid.
Its objective is to study the effect of a low radiation environment on the viability and growth of a microbial community recovered from high purity D₂O.

Interaction between host and pathogens under low-radiation background

Experiment developed by the EvolSysVir group (evolutionary systems virology) of the Institute for Integrative Systems Biology (I^²SysBio).
Characterization of Orsay virus infection dynamics in Caenohabditis elegans under muon-free conditions.

Genetic radiation tolerance

Experiment developed by the Translational Synthetic Biology group of the Pompeu Fabra University.

Its objective is to investigate the molecular basis of the effect of environmental radiation on the genomic integrity of prokaryotic and eukaryotic model organisms.

Luria-Delbrück 2.0

Experiment developed by TheSiMBioSys group (theoretical and in silico modeling of biological systems) of the Institute for Integrative Systems Biology (I^²SysBio).

Fluctuation test to measure the rate of microbial mutations in a low radiation environment.

Yeast chronological aging and mutation rate under low-radiation conditions

Experiment developed jointly by the Computational Synthetic Biology and Industrial Yeasts Biotechnology groups of the Institute for Integrative Systems Biology (I²SysBio).
The aim of this project is to study chronological ageing in yeast, using the Saccharomyces cerevisiae strain, and the mutation rate in a low-radiation environment.

Multicellular structure formation in response to low level background radiation.

Experiment developed by the Multicellgenome group of the Institute of Evolutionary Biology (IBE – Barcelona).
The aim of this proposal is to study cellular organisation in response to a low background radiation environment, using models of unicellular near Metazoa, which form multicellular structures during their life cycle or under external stimuli.

Ticking of epigenetic and senescence aging clocks in cosmic silence

Experiment developed by the Metabolism and Cancer group of the Institute for Biomedical Research of Girona (IDIBGI).
This experiment aims to study the primordial nature of the epigenetic clocks of ageing and senescence, measuring their functioning and timing capacity in an environment of ‘cosmic silence’.

Unravelling the mechanisms of the effects of low-dose ionising radiation on living systems

The aim of this proposal is to study how a low radiation environment can contribute to the appearance of alterations in subcellular enzymatic reactions, mitochondrial function, and direct and indirect DNA damage.

In order to do so, chemical enzymatic reactions involved in cellular protection against oxidative damage and mitochondrial function in yeast will be studied in this underground environment.

Learning from microgravity and non-cosmic radiation in Fishnauts (GraCosFish)

Experiment developed by the Repro-Immune Team (RIT) of the Instituto Ciencias del Mar (Barcelona), in collaboration with staff from IFREMER (French Institute for Ocean Science).

The aim of the project is to study the effects of microgravity and the absence of radiation, isolated or combined, on two species of fish during their early development.

Effect of low radiation environment on the activity of antimicrobials (DarkABX)

Experiment developed by the Mycobacterial Genetics group (Antibiotics Team), University of Zaragoza.

The aim of this proposal is to demonstrate whether commonly used antibiotics and antimicrobial molecules, with known mechanisms of action, would have differential activity against different pathogens in low radiation environments compared to their surface activity.